AJP November 2018 Issue Highlights

Both biological and epidemiological studies have taught us that mood problems begin much earlier in childhood than we previously thought. Even in the preschool or early school-age years, we can see the initial signs of serious problems with major depressive disorder. Much of the research has been on clinical presentation or biological correlates, but Luby and colleagues provide an important…

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AJP October 2019 Issue Highlights

There’s been tremendous research examining the neural correlates of schizophrenia using brain imaging. One of the exciting things to see in the field is that this research is beginning to move beyond cross-sectional studies that simply compare patients who are ill with patients who are healthy. Kochunov and colleagues present one of these new studies, and this study looks at…

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October 2019 AJP Editor Spotlight: White Matter in Schizophrenia Treatment Resistance

There’s been tremendous research examining the neural correlates of schizophrenia using brain imaging. One of the exciting things to see in the field is that this research is beginning to move beyond cross-sectional studies that simply compare patients who are ill with patients who are healthy. Kochunov and colleagues present one of these new studies, and this study looks at…

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November 2018 AJP Editor Spotlight: Brain Structure in Treated and Never-Treated Schizophrenia

We’ve known for many years that schizophrenia is associated with changes in brain structure. One of the major questions from this research concerns the origins of these changes. In particular, there’s a fair amount of data to suggest that at least some of these changes relate to medication exposure. Xiao and colleagues provide important new data in patients with schizophrenia…

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Dilemma of Dopamine

Hey guys, welcome to a short video on dopamine. This is position of dopamine. Its activity should be optimum in brain. If it decreases it causes Parkinson’s like symptoms and if it increases, it causes psychotic disorders. Typical antipsychotic drugs like chlorpromazine, thioridazine and haloperidol block dopamine receptors. So, they produce parkinsonism as side effect. And antiparkinsonian drugs like levodopa,…

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Pharmacology – ANTIPSYCHOTICS (MADE EASY)

in this lecture we are going to cover pharmacology of antipsychotics so antipsychotics are a class of drugs used primarily to treat psychotic disorders such as schizophrenia mania due to bipolar disorder and severe depression now in order to gain better understanding of mechanism of action of antipsychotic drugs first we need to discuss the role of dopamine in the…

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Quetiapine (Seroquel): What You Need To Know

Quetiapine is a second-generation antipsychotic approved by the FDA for schizophrenia, bipolar disorder, and as an add-on therapy for depression. It’s widely used for other conditions, including insomnia, anxiety, delirium, and as a single therapy for depression. Before discussing specific uses, it’s important to know the research on quetiapine, like many drugs, is far from ideal. The results can be…

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