Dilemma of Dopamine

Hey guys, welcome to a short video on dopamine. This is position of dopamine. Its activity should be optimum in brain. If it decreases it causes Parkinson’s like
symptoms and if it increases, it causes psychotic disorders. Typical antipsychotic drugs like chlorpromazine,
thioridazine and haloperidol block dopamine receptors. So, they produce parkinsonism as side effect. And antiparkinsonian drugs like levodopa,
carbidopa and entacapone increase dopamine activity in brain. So, they can cause psychosis as side effect. Fortunately, we also have drugs which are
exception to this. Atypical antipsychotics like clozapine, risperidone
and olanzapine work primarily through 5HT receptors. And centrally acting antimuscarinics used
in Parkinsonism, like trihexyphenidyl, biperiden and procyclidine work through muscarinic receptors. So, dopamine activity is affected least with
these drugs. That it. If you liked this video, please share it with
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